PCNA ubiquitylation ensures timely completion of unperturbed DNA replication in fission yeast

PCNA ubiquitylation on lysine 164 is required for DNA damage tolerance. In many organisms PCNA is also ubiquitylated in unchallenged S phase but the significance of this has not been established. Using Schizosaccharomyces pombe, we demonstrate that lysine 164 ubiquitylation of PCNA contributes to ef...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Daigaku, Yasukazu, Etheridge, Thomas J., Nakazawa, Yuka, Nakayama, Mayumi, Watson, Adam T., Miyabe, Izumi, Ogi, Tomoo, Osborne, Mark A., Carr, Antony M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440044/
https://ncbi.nlm.nih.gov/pubmed/28481910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006789
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