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Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons
Glucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neurons. We show that endothelial hypoxia-inducible factor 1α (HIF-1α) controls glucose uptake in the hypothalamus and that it is upregulated in conditions of undernourishment, during which POMC neuronal activity is decreased....
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| Udgivet i: | Diabetes |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Diabetes Association
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5440016/ https://ncbi.nlm.nih.gov/pubmed/28292966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1106 |
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