Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons

Glucose is the primary driver of hypothalamic proopiomelanocortin (POMC) neurons. We show that endothelial hypoxia-inducible factor 1α (HIF-1α) controls glucose uptake in the hypothalamus and that it is upregulated in conditions of undernourishment, during which POMC neuronal activity is decreased....

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Bibliographic Details
Published in:Diabetes
Main Authors: Varela, Luis, Suyama, Shigetomo, Huang, Yan, Shanabrough, Marya, Tschöp, Matthias H., Gao, Xiao-Bing, Giordano, Frank J., Horvath, Tamas L.
Format: Artigo
Language:Inglês
Published: American Diabetes Association 2017
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440016/
https://ncbi.nlm.nih.gov/pubmed/28292966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1106
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