Direct and Indirect Interactions between Calcineurin-NFAT and MEK1-Extracellular Signal-Regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth

MEK1, a member of the mitogen-activated protein kinase (MAPK) cascade that directly activates extracellular signal-regulated kinase (ERK), induces cardiac hypertrophy in transgenic mice. Calcineurin is a calcium-regulated protein phosphatase that also functions as a positive regulator of cardiac hyp...

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Detalhes bibliográficos
Main Authors: Sanna, Bastiano, Bueno, Orlando F., Dai, Yan-Shan, Wilkins, Benjamin J., Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544001/
https://ncbi.nlm.nih.gov/pubmed/15657416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.3.865-878.2005
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