Plasmid-free CRISPR/Cas9 genome editing in Plasmodium falciparum confirms mutations conferring resistance to the dihydroisoquinolone clinical candidate SJ733

Genetic manipulation of the deadly malaria parasite Plasmodium falciparum remains challenging, but the rise of CRISPR/Cas9-based genome editing tools is increasing the feasibility of altering this parasite’s genome in order to study its biology. Of particular interest is the investigation of drug ta...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Crawford, Emily D., Quan, Jenai, Horst, Jeremy A., Ebert, Daniel, Wu, Wesley, DeRisi, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439709/
https://ncbi.nlm.nih.gov/pubmed/28542423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178163
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