Direct modulation of secretory chloride channels by arachidonic and other cis unsaturated fatty acids.

The effect of fatty acids on Cl- channels and transepithelial Cl- secretion is investigated. Patch-clamp experiments show that arachidonic acid blocks Cl- channels in a dose-dependent manner. Kinetic analysis shows that the mean open time is decreased 10-fold with 25 microM arachidonic acid. There i...

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Bibliografiske detaljer
Main Authors: Hwang, T C, Guggino, S E, Guggino, W B
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC54396/
https://ncbi.nlm.nih.gov/pubmed/1696009
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