Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8

Regulation of intestinal T-cell responses is crucial for immune homeostasis and prevention of inflammatory bowel disease (IBD). A vital cytokine in regulating intestinal Tcells is transforming growth factor-β (TGFβ), which is secreted by cells as a latent complex that requires activation to function...

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Veröffentlicht in:Mucosal Immunol
Hauptverfasser: Fenton, TM, Kelly, A, Shuttleworth, EE, Smedley, C, Atakilit, A, Powrie, F, Campbell, S, Nishimura, SL, Sheppard, D, Levison, S, Worthington, JJ, Lehtinen, MJ, Travis, MA
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5439516/
https://ncbi.nlm.nih.gov/pubmed/27782111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.94
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