Blocking antibodies induced by immunization with a hypoallergenic parvalbumin mutant reduce allergic symptoms in a mouse model of fish allergy

BACKGROUND: Fish is a frequent elicitor of severe IgE-mediated allergic reactions. Beside avoidance, there is currently no allergen-specific therapy available. Hypoallergenic variants of the major fish allergen, parvalbumin, for specific immunotherapy based on mutation of the 2 calcium-binding sites...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Freidl, Raphaela, Gstoettner, Antonia, Baranyi, Ulrike, Swoboda, Ines, Stolz, Frank, Focke-Tejkl, Margarete, Wekerle, Thomas, van Ree, Ronald, Valenta, Rudolf, Linhart, Birgit
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438872/
https://ncbi.nlm.nih.gov/pubmed/27876628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2016.10.018
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