Combined inhibition of GLI and FLT3 signaling leads to effective anti-leukemic effects in human acute myeloid leukemia

Activation of the Hedgehog pathway has been implicated in the pathogenesis of several tumor types including myeloid leukemia. Previously we demonstrated that overexpression of Hedgehog downstream mediators GLI1/2 confers an adverse prognosis to patients with acute myeloid leukemia (AML) and is corre...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Latuske, Emily-Marie, Stamm, Hauke, Klokow, Marianne, Vohwinkel, Gabi, Muschhammer, Jana, Bokemeyer, Carsten, Jücker, Manfred, Kebenko, Maxim, Fiedler, Walter, Wellbrock, Jasmin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438723/
https://ncbi.nlm.nih.gov/pubmed/28418873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16304
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