Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture

BACKGROUND: Hyperexcitability of neuronal networks can lead to excessive release of the excitatory neurotransmitter glutamate, which in turn can cause neuronal damage by overactivating NMDA-type glutamate receptors and related signaling pathways. This process (excitotoxicity) has been implicated in...

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Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Miyamoto, Takashi, Stein, Liana, Thomas, Reuben, Djukic, Biljana, Taneja, Praveen, Knox, Joseph, Vossel, Keith, Mucke, Lennart
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438564/
https://ncbi.nlm.nih.gov/pubmed/28526038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0176-x
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