Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addition to synaptic loss. A dysfunctional ubiquitin prot...

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Détails bibliographiques
Publié dans:J Alzheimers Dis
Auteurs principaux: Alghamdi, Amani, Vallortigara, Julie, Howlett, David R., Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J., O’Brien, John T., Aarsland, Dag, Attems, Johannes, Francis, Paul T., Whitfield, David R.
Format: Artigo
Langue:Inglês
Publié: IOS Press 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438478/
https://ncbi.nlm.nih.gov/pubmed/28269775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160946
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