Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addition to synaptic loss. A dysfunctional ubiquitin prot...

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Dettagli Bibliografici
Pubblicato in:J Alzheimers Dis
Autori principali: Alghamdi, Amani, Vallortigara, Julie, Howlett, David R., Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J., O’Brien, John T., Aarsland, Dag, Attems, Johannes, Francis, Paul T., Whitfield, David R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: IOS Press 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438478/
https://ncbi.nlm.nih.gov/pubmed/28269775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160946
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