Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia

Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by α-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-β (Aβ) and hyperphosphorylated tau (tau) aggregates in addition to synaptic loss. A dysfunctional ubiquitin prot...

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Detaylı Bibliyografya
Yayımlandı:J Alzheimers Dis
Asıl Yazarlar: Alghamdi, Amani, Vallortigara, Julie, Howlett, David R., Broadstock, Martin, Hortobágyi, Tibor, Ballard, Clive, Thomas, Alan J., O’Brien, John T., Aarsland, Dag, Attems, Johannes, Francis, Paul T., Whitfield, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: IOS Press 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438478/
https://ncbi.nlm.nih.gov/pubmed/28269775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-160946
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