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G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β-Arrestin

Phosphorylation of G protein-coupled receptors (GPCRs) is a key event for cell signaling and regulation of receptor function. Previously, using tandem mass spectrometry, we identified two phosphorylation sites at the distal C-terminal tail of the chemokine receptor CXCR4, but were unable to determin...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Luo, Jiansong, Busillo, John M., Stumm, Ralf, Benovic, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438129/
https://ncbi.nlm.nih.gov/pubmed/28331048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106468
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