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Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1

Human steroidogenic cytochrome P450 17A1 (CYP17A1) is a bifunctional enzyme that performs both hydroxylation and lyase reactions, with the latter required to generate androgens that fuel prostate cancer proliferation. The steroid abiraterone, the active form of the only CYP17A1 inhibitor approved by...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Petrunak, Elyse M., Rogers, Steven A., Aubé, Jeffrey, Scott, Emily E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438109/
https://ncbi.nlm.nih.gov/pubmed/28373265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.117.075317
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