Treating sickle cell disease by targeting HbS polymerization

Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to form fibers that make red cells less flexible, most drugs currently being assessed in clinical trials are targeting the downstream sequelae of this primary event. Less attention has been devoted to investig...

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Bibliografiske detaljer
Udgivet i:Blood
Main Authors: Eaton, William A., Bunn, H. Franklin
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Perspective
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437829/
https://ncbi.nlm.nih.gov/pubmed/28385699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-02-765891
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