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HbS Binding to GP1bα Activates Platelets in Sickle Cell Disease

Intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our previous study showed that the binding of adult hemoglobin (HbA) to glycoprotein (GP) 1bα induced the activation of platelets. The elevated plasma Hb or platelet surface bound Hb positively correlated with platelet...

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Podrobná bibliografie
Vydáno v:PLoS One
Hlavní autoři: Annarapu, Gowtham K., Singhal, Rashi, Gupta, Avinash, Chawla, Sheetal, Batra, Harish, Seth, Tulika, Guchhait, Prasenjit
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148012/
https://ncbi.nlm.nih.gov/pubmed/27936141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167899
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