Inhibition of the Serotonin Transporter Is Altered by Metabolites of Selective Serotonin and Norepinephrine Reuptake Inhibitors and Represents a Caution to Acute or Chronic Treatment Paradigms

[Image: see text] Previous studies of transgenic mice carrying a single isoleucine to methionine substitution (I172M) in the serotonin transporter (SERT) demonstrated a loss of sensitivity to multiple antidepressants (ADs) at SERT. However, the ability of AD metabolites to antagonize SERT was not as...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Krout, Danielle, Rodriquez, Meghan, Brose, Stephen A., Golovko, Mikhail Y., Henry, L. Keith, Thompson, Brent J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437659/
https://ncbi.nlm.nih.gov/pubmed/27959497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.6b00343
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