Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor

[Image: see text] The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug–drug interaction. We describe herein the di...

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Autors principals: Dreyfus, Nicolas, Myers, Jason K., Badescu, Valentina O., de Frutos, Oscar, de la Puente, Maria Luz, Ding, Chunjin, Filla, Sandra A., Fynboe, Karsten, Gernert, Douglas L., Heinz, Beverly A., Hemrick-Luecke, Susan K., Johnson, Kirk W., Johnson, Michael P., López, Pilar, Love, Patrick L., Martin, Laura J., Masquelin, Thierry, McCoy, Michael J., Mendiola, Javier, Morrow, Denise, Muhlhauser, Mark, Pascual, Gustavo, Perun, Thomas J., Pfeifer, Lance A., Phebus, Lee A., Richards, Simon J., Rincón, Juan Antonio, Seest, Eric P., Shah, Jikesh, Shaojuan, Jia, Simmons, Rosa Maria A., Stephenson, Gregory A., Tromiczak, Eric G., Thompson, Linda K., Walter, Magnus W., Weber, Wayne W., Zarrinmayeh, Hamideh, Thomas, Craig E., Joshi, Elizabeth, Iyengar, Smriti, Johansson, Anette M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027471/
https://ncbi.nlm.nih.gov/pubmed/24900709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400049p
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