Discovery of a Potent, Dual Serotonin and Norepinephrine Reuptake Inhibitor

[Image: see text] The objective of the described research effort was to identify a novel serotonin and norepinephrine reuptake inhibitor (SNRI) with improved norepinephrine transporter activity and acceptable metabolic stability and exhibiting minimal drug–drug interaction. We describe herein the di...

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Main Authors: Dreyfus, Nicolas, Myers, Jason K., Badescu, Valentina O., de Frutos, Oscar, de la Puente, Maria Luz, Ding, Chunjin, Filla, Sandra A., Fynboe, Karsten, Gernert, Douglas L., Heinz, Beverly A., Hemrick-Luecke, Susan K., Johnson, Kirk W., Johnson, Michael P., López, Pilar, Love, Patrick L., Martin, Laura J., Masquelin, Thierry, McCoy, Michael J., Mendiola, Javier, Morrow, Denise, Muhlhauser, Mark, Pascual, Gustavo, Perun, Thomas J., Pfeifer, Lance A., Phebus, Lee A., Richards, Simon J., Rincón, Juan Antonio, Seest, Eric P., Shah, Jikesh, Shaojuan, Jia, Simmons, Rosa Maria A., Stephenson, Gregory A., Tromiczak, Eric G., Thompson, Linda K., Walter, Magnus W., Weber, Wayne W., Zarrinmayeh, Hamideh, Thomas, Craig E., Joshi, Elizabeth, Iyengar, Smriti, Johansson, Anette M.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2013
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027471/
https://ncbi.nlm.nih.gov/pubmed/24900709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400049p
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