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Locus-specific histone deacetylation using a synthetic CRISPR-Cas9-based HDAC
Efforts to manipulate locus-specific histone acetylation to assess their causal role in gene expression and cellular and behavioural phenotypes have been impeded by a lack of experimental tools. The Cas9 nuclease has been adapted to target epigenomic modifications, but a detailed description of the...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437308/ https://ncbi.nlm.nih.gov/pubmed/28497787 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15315 |
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