Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells

Nickel-containing compounds are widely used in industry. Nickel is a known human carcinogen that primarily affects the lungs. Proposed mechanisms of nickel-induced carcinogenesis include disruption of cellular iron homeostasis, generation of reactive oxygen species (ROS), and induction of hypoxia si...

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Vydáno v:J Biol Chem
Hlavní autoři: Son, Young-Ok, Pratheeshkumar, Poyil, Divya, Sasidharan Padmaja, Zhang, Zhuo, Shi, Xianglin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437238/
https://ncbi.nlm.nih.gov/pubmed/28330870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773986
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