Endogenous prostaglandin E(2) amplifies IL-33 production by macrophages through an E prostanoid (EP)(2)/EP(4)-cAMP-EPAC-dependent pathway

When activated through toll-like receptors (TLRs), macrophages generate IL-33, an IL-1 family member that induces innate immune responses through ST2 signaling. LPS, a TLR4 ligand, induces macrophages to generate prostaglandin E(2) (PGE(2)) through inducible COX-2 and microsomal PGE(2) synthase 1 (m...

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Vydáno v:J Biol Chem
Hlavní autoři: Samuchiwal, Sachin K., Balestrieri, Barbara, Raff, Hannah, Boyce, Joshua A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437228/
https://ncbi.nlm.nih.gov/pubmed/28341741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769422
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