An Expanded Role for HLA Genes: HLA-B Encodes a microRNA that Regulates IgA and Other Immune Response Transcripts

We describe a novel functional role for the HLA-B locus mediated by its intron-encoded microRNA (miRNA), miR-6891-5p. We show that in vitro inhibition of miR-6891-5p impacts the expression of nearly 200 transcripts within the B-lymphoblastoid cell line (B-LCL) COX, affecting a large number of metabo...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Chitnis, Nilesh, Clark, Peter M., Kamoun, Malek, Stolle, Catherine, Brad Johnson, F., Monos, Dimitri S.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437213/
https://ncbi.nlm.nih.gov/pubmed/28579988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00583
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