Targeting Ongoing DNA Damage in Multiple Myeloma: Effects of DNA Damage Response Inhibitors on Plasma Cell Survival

Human myeloma cell lines (HMCLs) and a subset of myeloma patients with poor prognosis exhibit high levels of replication stress (RS), leading to DNA damage. In this study, we confirmed the presence of DNA double-strand breaks (DSBs) in several HMCLs by measuring γH2AX and RAD51 foci and analyzed the...

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Udgivet i:Front Oncol
Main Authors: Herrero, Ana Belén, Gutiérrez, Norma Carmen
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Oncology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437203/
https://ncbi.nlm.nih.gov/pubmed/28580318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00098
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