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TRAF3 enhances TCR signaling by regulating the inhibitors Csk and PTPN22
The adaptor protein TNF receptor associated factor (TRAF) 3 is required for effective TCR signaling and normal T cell effector functions, and associates with the CD3/CD28 complex upon activation. To determine how TRAF3 promotes proximal TCR signaling, we studied TRAF3-deficient mouse and human T cel...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5437045/ https://ncbi.nlm.nih.gov/pubmed/28522807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-02280-4 |
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