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Development of a versatile oncolytic virus platform for local intra-tumoural expression of therapeutic transgenes

Oncolytic viruses which infect and kill tumour cells can also be genetically modified to express therapeutic genes that augment their anti-cancer activities. Modifying oncolytic viruses to produce effective cancer therapies is challenging as encoding transgenes often attenuates virus activity or pre...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Marino, Nalini, Illingworth, Sam, Kodialbail, Prithvi, Patel, Ashvin, Calderon, Hugo, Lear, Rochelle, Fisher, Kerry D., Champion, Brian R., Brown, Alice C. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436815/
https://ncbi.nlm.nih.gov/pubmed/28542292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177810
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