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A 3D fish liver model for aquatic toxicology: Morphological changes and Cyp1a induction in PLHC-1 microtissues after repeated benzo(a)pyrene exposures

To identify the potential environmental impacts of aquatic pollutants, rapid and sensitive screening tools are needed to assess adaptive and toxic responses. This study characterizes a novel fish liver microtissue model, produced with the cell line PLHC-1, as an in vitro aquatic toxicity testing pla...

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Detalhes bibliográficos
Publicado no:Aquat Toxicol
Main Authors: Rodd, April L., Messier, Norma J., Vaslet, Charles A., Kane, Agnes B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436724/
https://ncbi.nlm.nih.gov/pubmed/28282620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aquatox.2017.02.018
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