Nicotinamide metabolism regulates glioblastoma stem cell maintenance

Metabolic dysregulation promotes cancer growth through not only energy production, but also epigenetic reprogramming. Here, we report that a critical node in methyl donor metabolism, nicotinamide N-methyltransferase (NNMT), ranked among the most consistently overexpressed metabolism genes in gliobla...

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Udgivet i:JCI Insight
Main Authors: Jung, Jinkyu, Kim, Leo J.Y., Wang, Xiuxing, Wu, Qiulian, Sanvoranart, Tanwarat, Hubert, Christopher G., Prager, Briana C., Wallace, Lisa C., Jin, Xun, Mack, Stephen C., Rich, Jeremy N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436539/
https://ncbi.nlm.nih.gov/pubmed/28515364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90019
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