Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.

We describe here the involvement of calcium-activated neutral protease (CANP or calpain, EC 3.4.22.17) in calcium-dependent proteolytic processing of the precursor of human interleukin 1 alpha (IL-1 alpha) into mature IL-1 alpha. Calcium ionophore ionomycin enhanced proteolytic processing of pre-IL-...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Kobayashi, Y, Yamamoto, K, Saido, T, Kawasaki, H, Oppenheim, J J, Matsushima, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54362/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2115174/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.14.5548
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