Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examin...

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Vydáno v:Nat Commun
Hlavní autoři: Walsh, Ryan M., Shen, Erica Y., Bagot, Rosemary C., Anselmo, Anthony, Jiang, Yan, Javidfar, Behnam, Wojtkiewicz, Gregory J., Cloutier, Jennifer, Chen, John W., Sadreyev, Ruslan, Nestler, Eric J., Akbarian, Schahram, Hochedlinger, Konrad
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436068/
https://ncbi.nlm.nih.gov/pubmed/28485378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15142
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