Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice

PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examin...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Walsh, Ryan M., Shen, Erica Y., Bagot, Rosemary C., Anselmo, Anthony, Jiang, Yan, Javidfar, Behnam, Wojtkiewicz, Gregory J., Cloutier, Jennifer, Chen, John W., Sadreyev, Ruslan, Nestler, Eric J., Akbarian, Schahram, Hochedlinger, Konrad
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436068/
https://ncbi.nlm.nih.gov/pubmed/28485378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15142
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