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Heparin acts as a structural component of β-endorphin amyloid fibrils rather than a simple aggregation promoter

The aggregation promoter heparin is commonly used to study the aggregation kinetics and biophysical properties of protein amyloids. However, the underlying mechanism for amyloid promotion by heparin remains poorly understood. In the case of the neuropeptide β-endorphin that can reversibly adopt a fu...

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Detalhes bibliográficos
Publicado no:Chem Commun (Camb)
Main Authors: Nespovitaya, N., Mahou, P., Laine, R. F., Schierle, G. S. Kaminski, Kaminski, C. F.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5436042/
https://ncbi.nlm.nih.gov/pubmed/28067354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc09770g
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