Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these factors restricts astrocyte differentiation...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Genes Dev
Päätekijät: Bulstrode, Harry, Johnstone, Ewan, Marques-Torrejon, Maria Angeles, Ferguson, Kirsty M., Bressan, Raul Bardini, Blin, Carla, Grant, Vivien, Gogolok, Sabine, Gangoso, Ester, Gagrica, Sladjana, Ender, Christine, Fotaki, Vassiliki, Sproul, Duncan, Bertone, Paul, Pollard, Steven M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2017
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435889/
https://ncbi.nlm.nih.gov/pubmed/28465359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293027.116
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