Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

Glioblastoma multiforme (GBM) is an aggressive brain tumor driven by cells with hallmarks of neural stem (NS) cells. GBM stem cells frequently express high levels of the transcription factors FOXG1 and SOX2. Here we show that increased expression of these factors restricts astrocyte differentiation...

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Pubblicato in:Genes Dev
Autori principali: Bulstrode, Harry, Johnstone, Ewan, Marques-Torrejon, Maria Angeles, Ferguson, Kirsty M., Bressan, Raul Bardini, Blin, Carla, Grant, Vivien, Gogolok, Sabine, Gangoso, Ester, Gagrica, Sladjana, Ender, Christine, Fotaki, Vassiliki, Sproul, Duncan, Bertone, Paul, Pollard, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435889/
https://ncbi.nlm.nih.gov/pubmed/28465359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293027.116
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