Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice

Background/Aims: Nicotinic acid (NA), a lipid-lowering drug, serves as a source of NAD(+), the cofactor for Sirt1. Leucine (Leu) stimulates the AMPK/Sirt1 axis and amplifies the effects of other AMPK/Sirt1 activating compounds. Therefore, we tested the interactive effects of leucine and low dose NA...

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Vydáno v:Am J Cardiovasc Dis
Hlavní autoři: Bruckbauer, Antje, Banerjee, Jheelam, Cao, Quiang, Cui, Xin, Jing, Jia, Zha, Lin, Li, Fenfen, Xue, Bingzhong, Shi, Hang, Zemel, Michael B
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5435603/
https://ncbi.nlm.nih.gov/pubmed/28533928
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