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Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy
The dynamic of cancer is intimately linked to a dysregulation of the cell cycle and signalling pathways. It has been argued that selectivity of treatments could exploit loss of checkpoint function in cancer cells, a concept termed “cyclotherapy”. Quantitative approaches that describe these dysregula...
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| Publicado no: | PLoS Comput Biol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5435348/ https://ncbi.nlm.nih.gov/pubmed/28467408 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005529 |
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