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The role of histidines in amyloid β fibril assembly
Low pH has a strong stabilising effect on the fibrillar assembly of amyloid β, which is associated with Alzheimer's disease. The stabilising effect is already pronounced at pH 6.0, suggesting that protonation of histidines might mediate this effect. Through the systematic substitution of the th...
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| Опубликовано в: : | FEBS Lett |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5434815/ https://ncbi.nlm.nih.gov/pubmed/28267202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.12616 |
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