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Chemical synthesis of a homoserine-mutant of the antibacterial, head-to-tail cyclized protein AS-48 by α-ketoacid–hydroxylamine (KAHA) ligation

An antibacterial cyclic AS-48 protein was chemically synthesized by α-ketoacid–hydroxylamine (KAHA) ligation. Initial challenges associated with the exceptionally hydrophobic segments arising from the amphiphilic nature of the protein were resolved by the development of bespoke reaction conditions f...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Rohrbacher, Florian, Zwicky, André, Bode, Jeffrey W.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434751/
https://ncbi.nlm.nih.gov/pubmed/28580120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00789b
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