Interleukin-10-producing LAG3(+) regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis

BACKGROUND: Regulatory T cells (Tregs) play a role in the suppression of inflammation in autoimmune diseases, and lymphocyte activation gene 3 (LAG3) was reported as a marker of interleukin (IL)-10-producing Tregs. We aimed to clarify the function of human IL-10-producing CD4(+)CD25(−)LAG3(+) T cell...

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Publicado en:Arthritis Res Ther
Autores principales: Nakachi, Shinichiro, Sumitomo, Shuji, Tsuchida, Yumi, Tsuchiya, Haruka, Kono, Masanori, Kato, Rika, Sakurai, Keiichi, Hanata, Norio, Nagafuchi, Yasuo, Tateishi, Shoko, Kanda, Hiroko, Okamura, Tomohisa, Yamamoto, Kazuhiko, Fujio, Keishi
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5434528/
https://ncbi.nlm.nih.gov/pubmed/28511719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-017-1309-x
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