Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to destructive arthritis. Although the HLA class II locus is the strongest genetic risk factor for rheumatoid arthritis, the relationship between HLA class II alleles and lymphocyte activation remains unclear. We perfo...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nagafuchi, Yasuo, Shoda, Hirofumi, Sumitomo, Shuji, Nakachi, Shinichiro, Kato, Rika, Tsuchida, Yumi, Tsuchiya, Haruka, Sakurai, Keiichi, Hanata, Norio, Tateishi, Shoko, Kanda, Hiroko, Ishigaki, Kazuyoshi, Okada, Yukinori, Suzuki, Akari, Kochi, Yuta, Fujio, Keishi, Yamamoto, Kazuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935954/
https://ncbi.nlm.nih.gov/pubmed/27385284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29338
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