Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to destructive arthritis. Although the HLA class II locus is the strongest genetic risk factor for rheumatoid arthritis, the relationship between HLA class II alleles and lymphocyte activation remains unclear. We perfo...

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Dades bibliogràfiques
Publicat a:Sci Rep
Autors principals: Nagafuchi, Yasuo, Shoda, Hirofumi, Sumitomo, Shuji, Nakachi, Shinichiro, Kato, Rika, Tsuchida, Yumi, Tsuchiya, Haruka, Sakurai, Keiichi, Hanata, Norio, Tateishi, Shoko, Kanda, Hiroko, Ishigaki, Kazuyoshi, Okada, Yukinori, Suzuki, Akari, Kochi, Yuta, Fujio, Keishi, Yamamoto, Kazuhiko
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935954/
https://ncbi.nlm.nih.gov/pubmed/27385284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29338
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