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ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease in which upper and lower motoneurons degenerate leading to muscle wasting, paralysis and eventually death from respiratory failure. Several studies indicate that skeletal muscle contributes to disease progression; however the m...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Gonzalez, David, Contreras, Osvaldo, Rebolledo, Daniela L., Espinoza, Juan Pablo, van Zundert, Brigitte, Brandan, Enrique
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433732/
https://ncbi.nlm.nih.gov/pubmed/28520806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177649
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