Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

BACKGROUND: Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron an...

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Veröffentlicht in:Mult Scler J Exp Transl Clin
Hauptverfasser: Gresle, Melissa M, Liu, Yaou, Kilpatrick, Trevor J, Kemper, Dennis, Wu, Qi-Zhu, Hu, Bing, Fu, Qing-Ling, So, Kwok-Fai, Sheng, Guoqing, Huang, Guanrong, Pepinsky, Blake, Butzkueven, Helmut, Mi, Sha
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5433342/
https://ncbi.nlm.nih.gov/pubmed/28607723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2055217316641704
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