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Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve
BACKGROUND: Two ongoing phase II clinical trials (RENEW and SYNERGY) have been developed to test the efficacy of anti-LINGO-1 antibodies in acute optic neuritis and relapsing forms of multiple sclerosis, respectively. Across a range of experimental models, LINGO-1 has been found to inhibit neuron an...
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| Publicado en: | Mult Scler J Exp Transl Clin |
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| Autores principales: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
SAGE Publications
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433342/ https://ncbi.nlm.nih.gov/pubmed/28607723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2055217316641704 |
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