pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs

The replication and pathogenicity of influenza A viruses (IAVs) critically depend on their ability to tolerate the antiviral interferon (IFN) response. To determine a potential role for the IAV hemagglutinin (HA) in viral sensitivity to IFN, we studied the restriction of IAV infection in IFN-β-treat...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Gerlach, Thomas, Hensen, Luca, Matrosovich, Tatyana, Bergmann, Janina, Winkler, Michael, Peteranderl, Christin, Klenk, Hans-Dieter, Weber, Friedemann, Herold, Susanne, Pöhlmann, Stefan, Matrosovich, Mikhail
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432869/
https://ncbi.nlm.nih.gov/pubmed/28356532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00246-17
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