Targeting the centriolar replication factor STIL synergizes with DNA damaging agents for treatment of ovarian cancer

Advanced ovarian cancer is an incurable disease. Thus, novel therapies are required. We wished to identify new therapeutic targets for ovarian cancer. ShRNA screen performed in 42 ovarian cancer cell lines identified the centriolar replication factor STIL as an essential gene for ovarian cancer cell...

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發表在:Oncotarget
Main Authors: Rabinowicz, Noa, Mangala, Lingegowda S., Brown, Kevin R., Checa-Rodriguez, Cintia, Castiel, Asher, Moskovich, Oren, Zarfati, Giulia, Trakhtenbrot, Luba, Levy-Barda, Adva, Jiang, Dahai, Rodriguez-Aguayo, Cristian, Pradeep, Sunila, van Praag, Yael, Lopez-Berestein, Gabriel, David, Ahuvit, Novikov, Ilya, Huertas, Pablo, Rottapel, Robert, Sood, Anil K., Izraeli, Shai
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2017
主題:
Research Paper
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5432342/
https://ncbi.nlm.nih.gov/pubmed/28423708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16068
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