Differential effects of zinc binding on structured and disordered regions in the multidomain STIL protein

Binding of metal ions is an important regulatory mechanism in proteins. Specifically, Zn(2+) binding to disordered regions commonly induces a disorder to order transition and gain of structure or oligomerization. Here we show that simultaneous binding of Zn(2+) ions has different effects on structur...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Amartely, Hadar, David, Ahuvit, Shamir, Mai, Lebendiker, Mario, Izraeli, Shai, Friedler, Assaf
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2016
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6014068/
https://ncbi.nlm.nih.gov/pubmed/30155058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6sc00115g
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