Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo

Chronic pancreatitis (CP) is a fibro-inflammatory disease leading to pain, maldigestion, and pancreatic insufficiency. No therapeutic options exist due to a limited understanding of the biology of CP pathology. Recent findings implicate pancreatic stellate cells (PSC) as prominent mediators of infla...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Komar, Hannah M., Serpa, Gregory, Kerscher, Claire, Schwoegl, Erin, Mace, Thomas A., Jin, Ming, Yang, Ming-Chen, Chen, Ching-Shih, Bloomston, Mark, Ostrowski, Michael C., Hart, Phil A., Conwell, Darwin L., Lesinski, Gregory B.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431930/
https://ncbi.nlm.nih.gov/pubmed/28496202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01973-0
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