CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

Tumor-associated macrophages (TAMs) promote cancer cell proliferation, invasion, and metastasis by producing various mediators. Although preclinical studies demonstrated that TAMs preferentially express CD163 and CD204, the TAM subsets in oral squamous cell carcinoma (OSCC) remain unknown. In this s...

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Udgivet i:Sci Rep
Main Authors: Kubota, Keigo, Moriyama, Masafumi, Furukawa, Sachiko, Rafiul, Haque A. S. M., Maruse, Yasuyuki, Jinno, Teppei, Tanaka, Akihiko, Ohta, Miho, Ishiguro, Noriko, Yamauchi, Masaaki, Sakamoto, Mizuki, Maehara, Takashi, Hayashida, Jun-Nosuke, Kawano, Shintaro, Kiyoshima, Tamotsu, Nakamura, Seiji
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431876/
https://ncbi.nlm.nih.gov/pubmed/28496107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01661-z
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