CD163(+)CD204(+) tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma

Tumor-associated macrophages (TAMs) promote cancer cell proliferation, invasion, and metastasis by producing various mediators. Although preclinical studies demonstrated that TAMs preferentially express CD163 and CD204, the TAM subsets in oral squamous cell carcinoma (OSCC) remain unknown. In this s...

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Published in:Sci Rep
Main Authors: Kubota, Keigo, Moriyama, Masafumi, Furukawa, Sachiko, Rafiul, Haque A. S. M., Maruse, Yasuyuki, Jinno, Teppei, Tanaka, Akihiko, Ohta, Miho, Ishiguro, Noriko, Yamauchi, Masaaki, Sakamoto, Mizuki, Maehara, Takashi, Hayashida, Jun-Nosuke, Kawano, Shintaro, Kiyoshima, Tamotsu, Nakamura, Seiji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431876/
https://ncbi.nlm.nih.gov/pubmed/28496107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01661-z
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