A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic

Following our recent discovery of a new scaffold exhibiting significant neurotrophic and neurogenic activities, a structurally tweaked analogue, embodying a 2-oxa-spiro [5.4]decane framework, has been conceptualised and found to be more potent and versatile. It exhibits enhanced neurotrophic and neu...

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Pubblicato in:Sci Rep
Autori principali: Joshi, Pranav Chintamani, Samineni, Ramesh, Bhattacharya, Dwaipayan, Reddy, Bommana Raghunath, Veeraval, Lenin, Das, Tapatee, Maitra, Swati, Wahul, Abhipradnya Bipin, Karri, Shailaja, Pabbaraja, Srihari, Mehta, Goverdhan, Kumar, Arvind, Chakravarty, Sumana
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5431446/
https://ncbi.nlm.nih.gov/pubmed/28473714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-01297-z
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